Pharmacokinetics and pharmacodynamics of the cathepsin <scp>S</scp> inhibitor, <scp>LY</scp>3000328, in healthy subjects

Abstract

A specific inhibitor of CatS which is cleared quickly from plasma may produce a transient decrease in plasma CatS activity which is followed by a more prolonged increase in plasma CatS mass which may have implications for the future clinical development of inhibitors of CatS.