Concepedia

Synthesis, molecular modeling, and biological evaluation of quinazoline derivatives containing the 1,3,4-oxadiazole scaffold as novel inhibitors of VEGFR2

Fang Qiao, Yong Yin, Yuning Shen, She‐Feng Wang, Shao Sha, Xun Wu, Ai‐Min Lu, Chen Xu, Weiming Zhang, Hai‐Liang Zhu

RSC Advances · 2015 · 22 citations · 19 references

DOI

Concepts

Abstract

A series of 4-alkoxyquinazoline derivatives containing the 1,3,4-oxadiazole scaffold were designed and synthesized. Their inhibitory activities were tested against A549, MCF-7 and Hela. <bold>4j</bold> showed the most potent inhibitory activity and may be a potential anticancer agent.

References

19

Detailed analysis of grid‐based molecular docking: A case study of CDOCKER—A CHARMm‐based MD docking algorithm

Guosheng Wu, D. H. Robertson, Charles L. Brooks et al. · Journal of Computational Chemistry · 2003 · 1.6K citations

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Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

Jennifer L. Stamos, Mark X. Sliwkowski, Charles Eigenbrot · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Stephen R. Wedge, Donald Ogilvie, Michael Dukes et al. · PubMed · 2002 · 802 citations

, , +15

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

Michele McTigue, Brion W. Murray, Jeffrey H. Chen et al. · Proceedings of the National Academy of Sciences · 2012 · 571 citations · Full text

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Cyclooxygenase-2 Pathway Correlates with VEGF Expression in Head and Neck Cancer. Implications for Tumor Angiogenesis and Metastasis

Oreste Gallo, Alessandro Franchi, Lucia Magnelli et al. · Neoplasia · 2001 · 294 citations · Full text

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