ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

Knut Erik Berge, Hui Tian, Gregory A. Graf et al. · Science · 2000 · 1.6K citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell · 1993 · 1.5K citations

Hepatology, Biochemistry, Biliary Tract +11

Disruption of <i>Abcg5</i> and <i>Abcg8</i> in mice reveals their crucial role in biliary cholesterol secretion

Liqing Yu, Robert E. Hammer, Jia Li-Hawkins et al. · Proceedings of the National Academy of Sciences · 2002 · 709 citations

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

Mi‐Hye Lee, Kangmo Lu, Star Hazard et al. · Nature Genetics · 2001 · 685 citations · Full text

Oxysterol, Biochemistry, Lipid Nutrition +8

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Liqing Yu, Jia Li-Hawkins, Robert E. Hammer et al. · Journal of Clinical Investigation · 2002 · 640 citations · Full text

Cholesterol Synthesis, Oxidative Stress, Biliary Cholesterol Secretion +17