Concepedia

Saturation of Multidrug-Resistant Protein 2 (Mrp2/Abcc2)-Mediated Hepatobiliary Secretion: Nonlinear Pharmacokinetics of a Heterocyclic Compound in Rats after Intravenous Bolus Administration

Yiding Hu, Kathleen E. Sampson, Bruce R. Heyde, Kathy M. Mandrell, Na Li, Anup Zutshi, Yurong Lai

Drug Metabolism and Disposition · 2009 · 10 citations · 19 references

DOI

Concepts

References

19

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

Michiko Suzuki, Hiroshi Suzuki, Yoshikazu Sugimoto et al. · Journal of Biological Chemistry · 2003 · 342 citations · Full text

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BindingDB Entry 50042069: Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

PubMed · 2013 · 172 citations · Full text

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Differential Expression of Mouse Hepatic Transporter Genes in Response to Acetaminophen and Carbon Tetrachloride

Lauren M. Aleksunes, Angela M. Lucas Slitt, Nathan J. Cherrington et al. · Toxicological Sciences · 2004 · 125 citations

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Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human

Meng Li, Haodan Yuan, Na Li et al. · European Journal of Pharmaceutical Sciences · 2008 · 111 citations

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Temocaprilat, a Novel Angiotensin-Converting Enzyme Inhibitor, is Excreted in Bile via an ATP-dependent Active Transporter (cMOAT) That is Deficient in Eisai Hyperbilirubinemic Mutant Rats (EHBR)

Hitoshi Ishizuka, K Konno, Hideo Naganuma et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 86 citations · Full text

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