Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

Yan Zhao, Veena R. Agarwal, Carole R. Mendelson et al. · Endocrinology · 1996 · 424 citations

Life Sciences, Molecular Biology, Oncology +16

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients.

Jörge R. Pasqualini, Gérard S. Chetrite, Charla M. Blacker et al. · The Journal of Clinical Endocrinology & Metabolism · 1996 · 412 citations · Full text

Life Sciences, Biochemistry, Oncology +9

Nonsteroidal Antiinflammatory Drugs and Breast Cancer

Randall E. Harris, Kadambari K. Namboodiri, William B. Farrar · Epidemiology · 1996 · 344 citations

Medicine, Oncology, Pharmacology +13

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

S E Bulun, Thomas M Price, Mala Mahendroo et al. · The Journal of Clinical Endocrinology & Metabolism · 1993 · 336 citations

Life Sciences, Cancer Biology, Endocrinology +17

The importance of local synthesis of estrogen within the breast

William R. Miller, John S. O’Neill · Steroids · 1987 · 281 citations

Life Sciences, Biochemistry, Endocrinology +12