Dioxygenation of cysteamine to hypotaurine at a tris(pyrazolyl)borate iron(<scp>ii</scp>) unit – cysteamine dioxygenase mimicking?

Abstract

A novel complex Tp(Me,Ph)Fe(SCH2CH2NH2) has been synthesized as a speculative model for ADO. Indeed its reaction with O2 led to the dioxygenation of the S atom and thus to hypotaurine. This finding may allow us to draw conclusions on the constitution of the ADO active site, whose structure is still unknown.