Apolipoprotein E (<i>APOE</i>) genotype regulates body weight and fatty acid utilization—Studies in gene‐targeted replacement mice

Abstract

Our data suggest that APOE3 is associated with the potential to more efficiently harvest dietary energy and to deposit fat in adipose tissue, while APOE4 carriers tend to increase fatty acid mobilization and utilization as fuel substrates especially under high-fat intake. The different handling of dietary energy may have contributed to the evolution and worldwide distribution of the ε3 allele.