Concepedia

Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin

Fabio Bellina, Silvia Cauteruccio, Susanna Monti, Renzo Rossi

Bioorganic & Medicinal Chemistry Letters · 2006 · 114 citations · 20 references

DOI

Concepts

References

20

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

Raimond B. G. Ravelli, Benoı̂t Gigant, Patrick A. Curmi et al. · Nature · 2004 · 1.6K citations

, , +14

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 789 citations

, , +11

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

G. Dark, S A Hill, Vivien E. Prise et al. · PubMed · 1997 · 624 citations

, , +13

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues:  Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Le Wang, Keith W. Woods, Qun Li et al. · Journal of Medicinal Chemistry · 2002 · 421 citations · Full text

, , +14

A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

Tam Luong Nguyen, Connor F. McGrath, Ann Hermone et al. · Journal of Medicinal Chemistry · 2005 · 287 citations

, , +17