Angewandte Chemie International Edition · 2003 · 90 citations · 38 references
PharmacyChemistryCombinatorial ChemistryDrug DiscoveryStructural BiologyMacrocycle SynthesisRetrosynthetic AnalysisRing-forming ReactionsTemplate-based Retrosynthesis
“One ring to bind them”: The Borromean link, which consists of three rings connected such that no two are concatenated, is a challenging synthetic target. The synthesis of an orthogonal two-ring system that could be a precursor for such a link was prepared from a polypyridine template (see picture).
38