CFTR potentiator therapy ameliorates impaired insulin secretion in CF patients with a gating mutation

Cystic Fibrosis–Related Diabetes: Current Trends in Prevalence, Incidence, and Mortality

Antoinette Moran, Jordan Dunitz, Brandon M. Nathan et al. · Diabetes Care · 2009 · 645 citations · Full text

Medicine, Endocrinology, Pediatrics +14

Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation

K. De Boeck, À. Munck, Seth Walker et al. · Journal of Cystic Fibrosis · 2014 · 386 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner

Paul D. W. Eckford, Canhui Li, Mohabir Ramjeesingh et al. · Journal of Biological Chemistry · 2012 · 308 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: a small pilot study

Melena D. Bellin, Theresa A. Laguna, Janice Leschyshyn et al. · Pediatric Diabetes · 2013 · 193 citations

Medicine, Endocrinology, Pharmacology +17

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

Hui Chen, Ye Chun Ruan, Xue Lian Zhang et al. · Nature Communications · 2014 · 154 citations · Full text

Life Sciences, Endocrinology, Physiology +17