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Tolerance of Skin Homografts Induced in Adult Mice by Multiple Injections of Homologous Spleen Cells.
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1961
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Multiple InjectionsCell TherapyLymphocyte DevelopmentImmunologyTissue TransplantationTolerant StateDermatologyF1 Hybrid StrainRegenerative MedicineExperimental DermatologyCell TransplantationKnockout MouseSkin DevelopmentTransplantationXenotransplantationCutaneous BiologySelf-toleranceAutoimmunityTolerance InductionCell BiologySkin Homo-graftsSkin Homografts InducedMedicineHomologous Spleen CellsGraft Rejection
1. Adult mice of the Z(C3H) strain have been made tolerant of skin homo-grafts of the(A X Z) F1 hybrid strain by repeated intravenous and intraperitoneal injections of homologous spleen cells. 2. Repeated intraperitoneal injections of homologous spleen cells generally failed to induce a tolerant state, although 3/75 recipients accepted the homologous skin homotransplant.