Applied Physics Letters · 2005 · 78 citations · 13 references
EngineeringBioengineeringCell BiologyBiosensorsElectrochemistrySensorsBiological SensorsCell-based BiosensorsElectrical CharacterizationElectron MicroscopyMicroscale BiosensorsScanning Probe MicroscopyAmbient SensingChargesDetector Spatial ResolutionElectrochemical SensingElectron Probe MicroanalysisEnvironmental Sensing ProbesSpatial Resolution MeasurementSurface Charge Measurement
We describe probes of a local electric field, which are capable of detecting an electric charge as small as the charge of one electron e, operational under ambient conditions and having a spatial resolution down to 100nm. The submicron-sized probes were made from a high-density high-mobility two-dimensional electron gas, which is sensitive to the presence of electric charges near its surface. We demonstrate the possibility of using such microprobes for life-science applications by measuring an electric response of individual yeast cells to abrupt changes in their environment.
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M. Nonnenmacher, M. O’Boyle, H. K. Wickramasinghe · Applied Physics Letters · 1991 · 2.3K citations
Natural Sciences, Materials Engineering, Materials Science +17
Measurements of Coulomb blockade with a noninvasive voltage probe
Mark Field, C. G. Smith, M. Pepper et al. · Physical Review Letters · 1993 · 617 citations