Naloxone Activation of μ-Opioid Receptors Mutated at a Histidine Residue Lining the Opioid Binding Cavity

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

Richard A. Henderson, J.M. Baldwin, T.A. Ceska et al. · Journal of Molecular Biology · 1990 · 3K citations

Life Sciences, Biochemistry, Biophysics +12

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Cloning of a Delta Opioid Receptor by Functional Expression

Christopher J. Evans, Duane E. Keith, Heather Morrison et al. · Science · 1992 · 1.2K citations

Medicine, Molecular Biology, Pharmacology +17