Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria Parasites

Abstract

Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active-site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500674_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.