Concepedia

Publication | Open Access

Enantioselective metabolism of primaquine by human CYP2D6

DOIFull Paper Access

32

Citations

27

References

2014

Year

Pius S. Fasinu, Babu L. Tekwani, NP Dhammika Nanayakkara, Bharathi Avula, HMT Bandara Herath, Yan‐Hong Wang, Vijender R. Adelli, Mahmoud A. ElSohly, Shabana I. Khan, Ikhlas A. Khan,
Malaria Journal

Abstract

The metabolism of primaquine by human CYP2D6 and the generation of its metabolites display enantio-selectivity regarding formation of hydroxylated product profiles. This may partly explain differential pharmacologic and toxicologic properties of primaquine enantiomers.

References

YearCitations

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