Roles of urokinase type plasminogen activator in a brain stab wound

Physiological consequences of loss of plasminogen activator gene function in mice

Peter Carmeliet, Luc Schoonjans, L Kieckens et al. · Nature · 1994 · 1.1K citations

Knockout Mouse, Induced Pluripotent Stem Cell, Signal Transduction +10

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

Stella E. Tsirka, Anna Gualandris, David G. Amaral et al. · Nature · 1995 · 656 citations

Neurobiology Of Disease, Neurophysiology, Excitotoxin-induced Neuronal Degeneration +9

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

Zu‐Lin Chen, Sidney Strickland · Cell · 1997 · 630 citations · Full text

Molecular Neuroscience, Neurophysiology, Cell Death +12

Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

Yanming F. Wang, Stella E. Tsirka, Sidney Strickland et al. · Nature Medicine · 1998 · 629 citations

Cerebral Vascular Regulation, Ischemic Stroke, Neurophysiology +14

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

Roberta Mazzieri, Laura Masiero, Lucia Zanetta et al. · The EMBO Journal · 1997 · 419 citations · Full text

Signal Transduction, Regulatory Mechanism, Urokinase-plasmin System +9