Concepedia

Discovery of Pyrrolo[2,3-b]pyrazines Derivatives as Submicromolar Affinity Activators of Wild Type, G551D, and F508del Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels

Sabrina Noël, Christelle Faveau, Caroline Norez, Christian Rogier, Yvette Mettey, Frédéric Becq

Journal of Pharmacology and Experimental Therapeutics · 2006 · 39 citations · 31 references

Concepts

MedicineMedicinal ChemistryPharmacologyDrug DiscoveryMolecular Cell BiologyMolecular PharmacologyChloride Channel BiophysicsCystic FibrosisLigand BindingCftr Protein FunctionChloride Channel PharmacologyIon Channel Structure-function RelationshipsPatch-clamp AnalysisPatch-clamp Data AnalysisPyrazine ChemistryPyrazole ChemistryWhole-cell Patch Clamp

References

31

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

John R. Riordan, Johanna M. Rommens, Bat-Sheva Kerem et al. · Science · 1989 · 7.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Gerene M. Denning, Matthew P. Anderson, Jane F. Amara et al. · Nature · 1992 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +9

An Animal Model for Cystic Fibrosis Made by Gene Targeting

John N. Snouwaert, Kristen K. Brigman, Anne M. Latour et al. · Science · 1992 · 919 citations

Life Sciences, Genetics, Molecular Genetics +15

Chloride impermeability in cystic fibrosis

Paul Quinton · Nature · 1983 · 758 citations

Natural Sciences, Physiology, Intracellular Transport +13

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 632 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10