A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

Abstract

These findings advance our understanding of virus cell entry and open new avenues for curative therapies. As glypicans have been shown to play a role in the control of cell division and growth regulation, virus-glypican 5 interactions may also play a role in the pathogenesis of virus-induced liver disease and cancer.