SNAP predicts effect of mutations on protein function

Abstract

Abstract Summary: Many non-synonymous single nucleotide polymor-phisms (nsSNPs) in humans are suspected to impact protein function. Here, we present a publicly available server implementation of the method SNAP (screening for non-acceptable polymorphisms) that predicts the functional effects of single amino acid substitutions. SNAP identifies over 80% of the non-neutral mutations at 77% accuracy and over 76% of the neutral mutations at 80% accuracy at its default threshold. Each prediction is associated with a reliability index that correlates with accuracy and thereby enables experimentalists to zoom into the most promising predictions. Availability: Web-server: http://www.rostlab.org/services/SNAP; downloadable program available upon request. Contact: bromberg@rostlab.org Supplementary information: Supplementary data are available at Bioinformatics online.