How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.4K citations

Life Sciences, Genetics, Immunology +13

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Markus Feuerer, Laura Herrero, Daniela Cipolletta et al. · Nature Medicine · 2009 · 2.1K citations · Full text

Life Sciences, Immunology, Physiology +16

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Deborah J. Lenschow, Lesley Rhee, Neda Ashourian et al. · Immunity · 2000 · 2K citations · Full text

Life Sciences, Cell Biology, Immunology +16

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Robert S. Wildin, Fred Ramsdell, Jane Peake et al. · Nature Genetics · 2001 · 1.9K citations

Medicine, Endocrinology, Pediatrics +17

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Jeong Kim, Jeffrey P. Rasmussen, Alexander Y. Rudensky · Nature Immunology · 2006 · 1.8K citations

Life Sciences, Genetics, Immunology +14