Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Howard A. Burris, Malcolm J. Moore, John Sahl Andersen et al. · Journal of Clinical Oncology · 1997 · 5.9K citations

Medicine, Oncology, Pharmacotherapy +16

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

Christiane J. Bruns, Carmen C. Solórzano, Matthew T. Harbison et al. · PubMed · 2000 · 501 citations

Medicine, Oncology, Pharmacology +17

Phase II study of gemcitabine in patients with advanced pancreatic cancer

J Carmichael, U. Fink, RC Russell et al. · British Journal of Cancer · 1996 · 370 citations · Full text

Medicine, Oncology, Pharmacology +11

Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways

Jing Fang, Chang Xia, Zongxian Cao et al. · The FASEB Journal · 2005 · 308 citations

Medicine, Oncology, Pharmacology +17

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

Didier Decaudin, Stephan Geley, Tamara Hirsch et al. · PubMed · 1997 · 302 citations

Life Sciences, Cell Biology, Oncology +11