<i>γ</i>‐secretase inhibitors exerts antitumor activity via down‐regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells

Abstract

The GSI L-685,458 may have a therapeutic value for the treatment of human tongue carcinoma. Moreover, the effects of L-685,458 in tumor inhibition may act partially via the modulation of Notch and NF-kappaB.