Vasopressin Stimulates Insulin Release from Islet Cells through V1b Receptors: a Combined Pharmacological/Knockout Approach

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

Daniel L. Cook, Nicholas M. Hales · Nature · 1984 · 1.2K citations

Life Sciences, Cell Biology, Physiology +16

Molecular cloning and expression of a rat Via arginine vasopressin receptor

Alain Morel, Anne‐Marie O’Carroll, Michael Brownstein et al. · Nature · 1992 · 482 citations

Life Sciences, Pharmacology, Physiology +5

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V _1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

Guy Griebel, Jacques Simiand, Claudine Serradeil‐Le Gal et al. · Proceedings of the National Academy of Sciences · 2002 · 462 citations · Full text

Medicine, Neuroscience, Pharmacology +17