Effects of dietary fat on the uptake and clearance of 7,12-dimethylbenz(alpha)anthracene by rat mammary tissue.

Abstract

The concentration of 7,12-dimethylbenz( α )anthracene (DMBA) in mammary tissue was determined at different time intervals following its administration, in a single dose, to female Sprague-Dawley rats maintained on 3 different semisynthetic diets: low fat, high coconut oil, and high corn oil. In general, the rate of uptake and clearance of the carcinogen was similar in the 3 groups, with a peak concentration occurring 6 to 12 hours after its administration. At 6 hours the tissue level of DMBA in coconut oil fed rats was significantly lower than in the other 2 groups. However, the data obtained could not fully explain the effects of dietary fat upon DMBA mammary carcinogenesis.