Real‐Time In Situ Powder X‐ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals

Abstract

Looking in: The penetrating power of high-energy X-rays provides a means to monitor in situ and in real time the course of ball-milling reactions of organic pharmaceutical solids by detecting crystalline phases and assessing the evolution of their particle sizes. Upon switching from neat grinding to liquid-assisted grinding, cocrystal formation is enabled or tremendously accelerated, while the reaction mechanism alters its course.