Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 - Concepedia

Concepedia

Publication | Open Access

Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

DOI Full Paper Access

127

Citations

22

References

2008

Year

Tiina T. Tuomisto, Henri Lumivuori, Emilia Kansanen, Sanna-Kaisa Häkkinen, Mikko P. Turunen, Johannes V. van Thienen, Anton J.G. Horrevoets, Anna–Liisa Levonen, Seppo Ylä‐Herttuala

Cardiovascular Research

Abstract

Simvastatin has a strong anti-inflammatory effect on HPBM cells including upregulation of the atheroprotective factor KLF-2. This may partly explain the beneficial effects of statins on cardiovascular diseases.

References

	Year	Citations

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