Concepedia

SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa

Joanne M. Smallheer, Richard Alexander, Jianmin Wang, Shuaige Wang, Suanne K. Nakajima, Karen A. Rossi, Angela Smallwood, Frank Barbera, Debra Burdick, Joseph M. Luettgen,

Bioorganic & Medicinal Chemistry Letters · 2004 · 41 citations · 14 references

DOIFull text

Open access

Concepts

References

14

The Protein Data Bank

Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations

, , +10

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.

Hans Brandstetter, Margit Bauer, R. Huber et al. · Proceedings of the National Academy of Sciences · 1995 · 283 citations

, , +17

X-ray Structure of Active Site-inhibited Clotting Factor Xa

Hans Brandstetter, Anja Kühne, Wolfram Bode et al. · Journal of Biological Chemistry · 1996 · 278 citations · Full text

, , +17

The selective inhibition of thrombin by peptides of boroarginine.

Charles A. Kettner, Lawrence J. Mersinger, Robert M. Knabb · Journal of Biological Chemistry · 1990 · 253 citations · Full text

, , +13

Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

, , +11