Site‐Specific Incorporation of Methyl‐ and Acetyl‐Lysine Analogues into Recombinant Proteins

Abstract

Location, location, location: A new chemoselective method to site- and degree-specifically install lysine analogues into recombinant proteins provides facile access to near-homogeneously methylated and acetylated histone analogues (see scheme; R1, R2, R3=H, Me, acetyl), which can be used to study the impact of histone modification on chromatin structure and function. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.