Concepedia

Prediction of Warfarin Dose Reductions in Puerto Rican Patients, Based on Combinatorial CYP2C9 and VKORCI Genotypes

Isa Ivette Valentin, Joan Vazquez, Giselle Rivera-Miranda, Richard L. Seip, Meredith Velez, Mohan Kocherla, Kali Bogaard, Ignacio Cruz‐González, Carmen L. Cadilla, Jessica Y. Renta,

Annals of Pharmacotherapy · 2012 · 18 citations · 41 references

DOI

Abstract

This study laid important groundwork for supporting a prospective pharmacogenetic trial in Puerto Ricans to detect the benefits of incorporating relevant genomic information into a customized DNA-guided warfarin dosing algorithm.

References

41

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

New England Journal of Medicine · 2009 · 1.6K citations · Full text

The Pharmacology and Management of the Vitamin K Antagonists

Jack Ansell, Jack Hirsh, L. Poller et al. · CHEST Journal · 2004 · 1.5K citations

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Effect of <i>VKORC1</i> Haplotypes on Transcriptional Regulation and Warfarin Dose

Mark J. Rieder, Alexander P. Reiner, Brian F. Gage et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations

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Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation

Elaine M. Hylek, Carmella Evans‐Molina, Carol Shea et al. · Circulation · 2007 · 1.1K citations · Full text