A Combination of Multisite Phosphorylation and Substrate Sequestration Produces Switchlike Responses

An amplified sensitivity arising from covalent modification in biological systems.

Albert Goldbeter, Daniel E. Koshland · Proceedings of the National Academy of Sciences · 1981 · 1.2K citations

Modified Protein, Biochemistry, Natural Sciences +14

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Chi‐Ying F. Huang, James E. Ferrell · Proceedings of the National Academy of Sciences · 1996 · 1.2K citations · Full text

Molecular Biology, Oocyte Maturation, Cytoskeleton +18

The Biochemical Basis of an All-or-None Cell Fate Switch in <i>Xenopus</i> Oocytes

James E. Ferrell, Eric M. Machleder · Science · 1998 · 1.1K citations

Oocyte, Maturation-inducing Hormone Progesterone, Biochemical Basis +24

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

Piers Nash, Xiaojing Tang, Stephen Orlicky et al. · Nature · 2001 · 754 citations

Genome Instability, Signal Transduction, Cell Regulation +10

Ultrasensitivity and noise propagation in a synthetic transcriptional cascade

Sara Hooshangi, Stephan Y. Thiberge, Ron Weiss · Proceedings of the National Academy of Sciences · 2005 · 513 citations · Full text

Engineering, Molecular Biology, Synthetic Circuit +20