Dimethyl fumarate induces necroptosis in colon cancer cells through <scp>GSH</scp> depletion/<scp>ROS</scp> increase/<scp>MAPKs</scp> activation pathway

Abstract

DMF but not its metabolite MMF induced necroptosis in colon cancer cells through a mechanism involving the depletion of GSH, an increase in ROS and activation of MAPKs.