Concepedia

4-Hydroxy-1-(3-pyridyl)-1-butanone, an Indicator for 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone–Induced DNA Damage, Is Not Detected in Human Pancreatic Tissue

Bogdan Prokopczyk, Gerhard Leder, Neil Trushin, A. J. Cunningham, Shobha A. Akerkar, Brian Pittman, Marco Ramadani, Joern Straeter, H. G. Beger, Doris Henne‐Bruns,

Cancer Epidemiology Biomarkers & Prevention · 2005 · 16 citations · 6 references

DOI

Concepts

Abstract

Tobacco smoking is the only known etiologic agent that causes pancreatic cancer. The tobacco-specific nitrosamine 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone (NNK) is a potent carcinogen in laboratory rodents that, independent of the route of administration, induces primarily lung adenocarcinoma

References

6

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Identification of Tobacco-Derived Compounds in Human Pancreatic Juice

Bogdan Prokopczyk, Dietrich Hoffmann, Matthew Bologna et al. · Chemical Research in Toxicology · 2002 · 107 citations

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Comparison of DNA adduct levels associated with oxidative stress in human pancreas

Fred F. Kadlubar, Kristin E. Anderson, Nicholas P. Lang et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 1998 · 102 citations

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Identification of O<sup>2</sup>-Substituted Pyrimidine Adducts Formed in Reactions of 4-(Acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA

Stephen S. Hecht, Peter W. Villalta, Shana J. Sturla et al. · Chemical Research in Toxicology · 2004 · 64 citations

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Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate

Carcinogenesis · 1998 · 33 citations · Full text

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