Abnormal Termination of Ca ²⁺ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

Abstract

These results provide the first evidence that the NH2-terminal region of RyR2 is an important determinant of Ca2+ release termination, and that abnormal fractional Ca2+ release attributable to aberrant termination of Ca2+ release is a common defect in RyR2-associated cardiomyopathies.