Ruiwu Wang

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca ²⁺ release (SOICR)

Dawei Jiang, Bailong Xiao, Dongmei Yang et al. · Proceedings of the National Academy of Sciences · 2004 · 432 citations · Full text

Cardiac Muscle, Heart Failure, Spontaneous Ca2+ Release +20

Enhanced Store Overload–Induced Ca ²⁺ Release and Channel Sensitivity to Luminal Ca ²⁺ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death

Dawei Jiang, Ruiwu Wang, Bailong Xiao et al. · Circulation Research · 2005 · 348 citations

Cardiac Muscle, Store Ca2+ Overload, Sudden Death +19

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

Wei Peng, Huaizong Shen, Jianping Wu et al. · Science · 2016 · 275 citations

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

Qiang Zhou, Jianmin Xiao, Dawei Jiang et al. · Nature Medicine · 2011 · 250 citations

Ca2+ Release, Signal Transduction, Biochemistry +4

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

Wenqian Chen, Ruiwu Wang, Biyi Chen et al. · Nature Medicine · 2014 · 194 citations · Full text

Cardiac Muscle, Molecular Physiology, Signal Transduction +12