Concepedia

The farnesyl transferase inhibitor R115777 (Zarnestra®) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa®) and Pamidronate

Michele Caraglia, Anna Maria D’Alessandro, Monica Marra, G. Giuberti, Giovanni Vitale, Caterina Viscomi, Annamaria Colao, Salvatore Del Prete, Pierosandro Tagliaferri, Pierfrancesco Tassone,

Oncogene · 2004 · 74 citations · 38 references

DOI

Concepts

References

38

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

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All ras proteins are polyisoprenylated but only some are palmitoylated

John F. Hancock, Anthony I. Magee, Julie E. Childs et al. · Cell · 1989 · 1.8K citations

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Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

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Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

D. E. Hughes, Kenneth R. Wright, Harry L. Uy et al. · Journal of Bone and Mineral Research · 1995 · 1K citations

, , +17

Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid

Jeanette M. Wood, Karine Bonjean, Stephan Ruetz et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 851 citations

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