Dual Activation and Inhibition of Adenylyl Cyclase by Cannabinoid Receptor Agonists: Evidence for Agonist-Specific Trafficking of Intracellular Responses

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Murielle Rinaldi‐Carmona, Francis Barth, Michel Héaulme et al. · FEBS Letters · 1994 · 1.8K citations · Full text

Medicine, Neuroscience, Pharmacology +14

Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

Christian C. Felder, Kelly E. Joyce, Eileen M. Briley et al. · Molecular Pharmacology · 1995 · 879 citations

Medicine, Pharmacology, Cell Signaling +7

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a G_sLinkage to the CB1 Receptor

Michelle Glass, Christian C. Felder · Journal of Neuroscience · 1997 · 636 citations · Full text

Life Sciences, Neurobiology, Pharmacology +17

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

Alex D. Federman, Bruce R. Conklin, Karen Schrader et al. · Nature · 1992 · 633 citations

Life Sciences, Biochemistry, Molecular Biology +16