Publication | Closed Access
Increase in Number of Splenic Transplantable Colony-Forming Units in the SJL/J Mice After Infection With Rauscher Leukemia Virus<xref ref-type="fn" rid="FN2">2</xref>
25
Citations
0
References
1972
Year
Viral ReplicationLymphocyte DevelopmentImmunologyViral PathogenesisPathologyBlood CellImmune SystemTotal NumberSjl/j MiceHematologyRadiation OncologyCell TransplantationRauscher Leukemia VirusHealth SciencesXenotransplantationTransplantationSpleen SizeVirologyImmune SurveillanceHumoral ImmunityPathogenesisVirus-host InteractionMedicine
Previous experiments demonstrated that mice infected with Rauscher leukemia virus (RLV) possessed a significant resistance to the lethal effects of radiation. The present experiments were designed to determine whether changes in either the number of hematopoietic colony-forming units (CFU) or in the number of peripheral white cells might correlate with this resistance. The number of transplantable CFU in the spleens of SJL/J mice 14 days after they received an injection of RLV was measured relative to CFUs in the spleens of uninfected control mice. It was found that as a result of RLV infection the total number of transplantable splenic CFUs increased in the RLV-infected mice in proportion to the increase in spleen size. Conversely, no change was noted in either the total white blood cells or the lymphoid/myeloid ratio at 14 days after RLV injection, even though the leukemia could be demonstrated in the peripheral blood at later times.—J Natl Cancer Inst 49: 1101–1106, 1972.