OSI-211, a novel liposomal topoisomerase I inhibitor, is active in SCID mouse models of human AML and ALL

Nonparametric Estimation from Incomplete Observations

Edward L. Kaplan, Paul Meier · Journal of the American Statistical Association · 1958 · 7.8K citations

Public Health, Biostatistics, Mathematics +10

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

Randall K. Saiki, Teodorica L. Bugawan, Glenn T. Horn et al. · Nature · 1986 · 1.8K citations

Life Sciences, Genetics, Molecular Genetics +14

Randomized phase II study of two schedules of topotecan in previously treated patients with ovarian cancer: a National Cancer Institute of Canada Clinical Trials Group study.

Paul Hoskins, Elizabeth A. Eisenhauer, Sandra Beare et al. · Journal of Clinical Oncology · 1998 · 172 citations

Medicine, Oncology, Pharmacology +17

Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin.

A. Fujimori, W G Harker, Glenda Kohlhagen et al. · PubMed · 1995 · 153 citations

Life Sciences, Molecular Biology, Oncology +12

Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I

Michael J. Luzzio, Jeffrey M. Besterman, David L. Emerson et al. · Journal of Medicinal Chemistry · 1995 · 145 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15