Concepedia

Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma.

Teodora Ribarska, Marc Ingenwerth, Wolfgang Goering, Rainer Engers, Wolfgang A. Schulz

PubMed · 2010 · 51 citations · 50 references

Abstract

Epigenetic disturbances in the 7q21 cluster affect imprinted genes in a non-coordinate manner suggesting an unstable epigenetic state prone to selection for specific expression changes.

References

50

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

B Bernstein, Tarjei S. Mikkelsen, Xiaohui Xie et al. · Cell · 2006 · 5.4K citations · Full text

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Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Yeshayahu Schlesinger, Ravid Straussman, Ilana Keshet et al. · Nature Genetics · 2006 · 1.2K citations

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Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

Ryuichi Ono, Kenji Nakamura, Kimiko Inoue et al. · Nature Genetics · 2005 · 460 citations

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DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang et al. · Cancer Research · 2008 · 290 citations · Full text

Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

Michael T. McCabe, Johann C. Brandes, Paula M. Vertino · Clinical Cancer Research · 2009 · 254 citations · Full text

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