STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

Abstract

of a salicylate metabolite, gentisic acid. The re- lationships between the renal excretion of salicyl- ate and of urate are then examined by means of simultaneous clearance techniques, including studies under conditions of urine pH made to vary from markedly acid to markedly alkaline. Clearance data on the antagonistic effect of small doses of salicylate on probenecid uricosuria, and vice versa, also are presented. Finally, the im- plications of the results as a whole are considered in relation to current concepts of renal mecha- nisms for the excretion of salicylate and of urate, with special reference to inferences regarding the possibility of tubular excretion of urate in man.