Effect of Sodium Lactate Infusion on Urate Clearance in Man.

Abstract

SummaryRenal clearance studies are described which corroborate and extend earlier observations indicating that administration of sodium lactate in sufficient dosage results in a profound fall in urinary excretion of uric acid. Curate declined from a mean control level of 10.4 ml/min. to a mean minimum of 1.4 ml/min. The uricosuria produced by salicylate and probenecid was temporarily abolished by lactate. The significance of these findings is discussed.