THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN 1

TLDR

The study employed precipitation with cadmium sulfate, trichloroacetic acid, or tungstate followed by fusion analysis for direct determination of substituted hippuric acids. The measured renal clearances varied widely across derivatives, ranging from 0.01 to 0.4, indicating differential renal handling.

Abstract

6 4 0.1 to 0.3 5 xlo 0.3 to 1.97 8 4 0.13 to 0.26 63 0 to 0.31 m-Aminohippuric acid 5 2 0 to 0.06 2 ' 0 to 0.02 4 2 0 2 3 0 to 0.01 p-Amitohippuric acid 11i6 0 6 6 O to 0.18 9 c O to 0.10 8 6 O to 0.4 p-Aminohippuric acid 5 2 0 5 2 0 2 3 0 p-Acetylaminohippuric acid 28 0.08toO.1136 0 16 0 p-Acetylaminohippuric acid 2 2 0 1 ' 0 p-Aminomandelic acid 4 2 0 to 0.08 4 2 0 to 0.05 1 3 0.17 p-Aminophenylsuccinic acid 12 0.02 1 0.02 p-Aminophenaceturic acid 3 2 O to 0.01 Diodrast 9 2 0 1 ' 0.24 3 ' 0.24 to 0.35 p-Aminobenzoic acid 2 2 01 Precipitated with tungstate 1-5.2 Precipitated with cadmium sulfate 1-15.3 Diluted 1-2.5 with distilled water; precipitated with cadmium sulfate 1-5. 4 Precipitated with cadmium sulfate 1-5. 5 Precipitated with trichloroacetic acid 1-10.6 Diluted 1-2.5 with distilled water; precipitated with trichloroacetic acid 1-10. 7Diluted 1-2.5 with distilled water; precipitated with tungstate 1-5. 8Precipitated with trichloroacetic acid 1-5. 9Analyzed by fusion method.10 Direct rather than additive determination.