Concepedia

Uveal melanoma hepatic metastases mutation spectrum analysis using targeted next-generation sequencing of 400 cancer genes

Armelle Luscan, P-A. Just, Audrey Briand, Cyril Burin des Roziers, P. Goussard, Patrick Nitschké, Michel Vidaud, M.-F. Avril, Benoît Terris, Éric Pasmant

British Journal of Ophthalmology · 2014 · 35 citations · 20 references

DOI

Abstract

Further studies are required to confirm FBXW7 implication in UM tumorigenesis. Elucidating the molecular mechanisms underlying UM tumorigenesis holds the promise for novel and effective targeted UM therapies.

References

20

Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth, Michael D. McLellan, Fabio Vandin et al. · Nature · 2013 · 4.4K citations · Full text

Predicting Deleterious Amino Acid Substitutions

Pauline C. Ng, Steven Henikoff · Genome Research · 2001 · 2.7K citations · Full text

Detection of nonneutral substitution rates on mammalian phylogenies

Katherine S. Pollard, Melissa J. Hubisz, Kate R. Rosenbloom et al. · Genome Research · 2009 · 2.4K citations · Full text

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Catherine D. Van Raamsdonk, Vladimir Bezrookove, Gary Green et al. · Nature · 2008 · 1.6K citations · Full text

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Frequent Mutation of <i>BAP1</i> in Metastasizing Uveal Melanomas

J. William Harbour, Michael D. Onken, Elisha Roberson et al. · Science · 2010 · 1.5K citations · Full text