Journal of Biomedicine and Biotechnology · 2010 · 23 citations · 33 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyMedical OncologyCancer Cell SignalingCombination ChemotherapyCytotoxic ChemotherapyMalignant NeoplasmsPharmacodynamics Of Anticancer AgentsPharmacodynamics Of Anticancer DrugsAntiproliferative AgentsAntiproliferative Drug ActionCancer Cell Proliferation InhibitionCaspase CleavageCaspase SignalingChemotherapy For Pleural TumorsChemotherapy PharmacodynamicsChemotherapy-induced Apoptosis
Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents.
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