Phase II Trial of Interleukin 1 and Indomethacin in Treatment of Metastatic Melanoma

Abstract

Administration of higher doses of IL-1 alpha alone has been shown to produce hypotension in a large proportion of patients but can be given safely with phenylephrine support. Because of the association of hypotension with antitumor activity, treatment with higher IL-1 alpha doses alone may be a strategy for attaining better response rates.