IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

Ralf Schreck, P. Rieber, Patrick A. Baeuerle · The EMBO Journal · 1991 · 3.8K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +13

CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes et al. · The Journal of Experimental Medicine · 1991 · 1.7K citations · Full text

Functional Properties, Functional Interactions, Adaptive Immune System +14

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

Hsin‐Fang Yang‐Yen, Jean‐Claude Chambard, Yu-Lin Sun et al. · Cell · 1990 · 1.6K citations

Transcriptional Regulation, Signal Transduction, G Protein-coupled Receptor +9

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Fiona Harding, James G. McArthur, Jane A. Gross et al. · Nature · 1992 · 1.5K citations

Autoimmune Disease, T-cell Clones, Immunology +10

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

Markus Meyer, Ralf Schreck, Patrick A. Baeuerle · The EMBO Journal · 1993 · 1.3K citations · Full text

Inflammation, Redox Signaling, Intact Cells +12