Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals

TLDR

The study presents the results and data from testing 311 chemicals for mutagenicity in Salmonella typhimurium. The authors tested 311 chemicals in Salmonella typhimurium using a preincubation protocol without exogenous metabolic activation, with liver S‑9 from Aroclor‑induced male Sprague‑Dawley rats and Syrian hamsters, and volatile compounds in desiccators, retesting 35 chemicals in the same or different laboratories. Of the 311 chemicals, 120 were mutagenic or weakly mutagenic, 3 were questionable, 172 were non‑mutagenic, and 16 showed variable responses across laboratories.

Abstract

311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented.