Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

Abstract

Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][1] ). Although a few TK genes have been shown to be mutationally altered in specific human cancers ( [1][1] ), it is not