Concepedia

Activating Point Mutations

Activating Point Mutations is a type of genetic alteration characterized by a single nucleotide change within a receptor tyrosine kinase gene that results in constitutive activation of its kinase domain, thereby promoting oncogenic signaling.

879

Publications

78.6K

Citations

5.6K

Authors

1.4K

Institutions

Publications per year

2017–2026

100

Parents

Publications

879

ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

, , +17

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

Christian Thiede, Christine Steudel, Brigitte Mohr et al. · Blood · 2002 · 1.7K citations · Full text

, , +14

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

Rafael Bejar, Kristen E. Stevenson, Omar Abdel‐Wahab et al. · New England Journal of Medicine · 2011 · 1.6K citations

, , +17

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

Richard Cawthon, Robert B. Weiss, Gangfeng Xu et al. · Cell · 1990 · 1.1K citations

, , +12

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

Alix de La Coste, Béatrice Romagnolo, Pierre Billuart et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations · Full text

, , +17

1–5 of 879

Authors

5.6K

  1. TM
    Tony Mok

    Chinese University of Hong Kong, Hong Kong SAR China

    9 publications · 954 citations

    9

    h-index

  2. DS
    Demetrios�� Spandidos

    University of Crete, Greece

    9 publications · 279 citations

    9

    h-index

  3. FM
    Frank McCormick

    University of California, San Francisco, United States

    7 publications · 488 citations

    7

    h-index

  4. RA
    Robert A. Robinson

    University of Iowa, United States

    6 publications · 190 citations

    6

    h-index

  5. MA
    Marco A. Pierotti

    Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

    5 publications · 333 citations

    5

    h-index

1–5 of 5.6K

Institutions

1.4K

  1. National Institutes of Health

    Bethesda, United States

    28 h-index

    132 publications

    21K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    24 h-index

    114 publications

    36.5K citations

  3. National Cancer Institute

    Bethesda, United States

    23 h-index

    82 publications

    14.1K citations

  4. Inserm

    Paris, France

    20 h-index

    156 publications

    21.6K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    19 h-index

    121 publications

    21.1K citations

  6. Harvard University

    Cambridge, United States

    18 h-index

    95 publications

    17.4K citations

  7. The University of Texas Southwestern Medical Center

    Dallas, United States

    16 h-index

    43 publications

    4.1K citations

  8. University of California, San Francisco

    San Francisco, United States

    16 h-index

    65 publications

    9.5K citations

1–8 of 1.4K

Venues

  1. Journal of Biological Chemistry

    JBC · 60 publications · 4.7K citations

    41

    h-index

  2. PubMed

    Repository · 75 publications · 9.5K citations

    37

    h-index

  3. Molecular and Cellular Biology

    MCB · 35 publications · 2.9K citations

    27

    h-index

  4. Blood

    28 publications · 4.3K citations

    23

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 4.5K citations

    22

    h-index

1–5