A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17

Abstract

Summary The monoclonal antibody, H207 , raised against the human T‐cell‐derived acute lymphoblastic leukaemia line HSB‐2 , recognizes an antigen of apparent molecular weight 125000 which is coded for by the gene, MIC6 , on chromosome 17. Assignment was based on the pattern of reactivity with a panel of somatic cell hybrids. In particular, two hybrids containing only human chromosome 17 or a human translocation chromosome t( 3;17 ) (3pter‐3p11::17p11–17qter) respectively bound H207 , whilst their revertands did not. The H207 antigen has a general tissue distribution but is not found on B‐cell lines and is lacking from some T‐cell lines.